Pharmacokinetics of teicoplanin in patients undergoing continuous blood purification therapy

Adsorption of teicoplanin on PMMA and PS membrane, in vitro investigation

Abstract

Teicoplanin has been considered to be non-dialyzable and non-filterable due to its high protein binding. This study was performed to evaluate the pharmacokinetics of teicoplanin during continuous blood purification therapy using polysulfone (PS) and polymethylmethacrylate (PMMA) membrane. As a result, Teicoplanin was cleared much more rapidly from the blood by adsorption of PS and PMMA membrane. We recommend obligatory drug monitoring to achieve therapeutic plasma concentrations.