2012 Volume 3 Issue 2 Pages 141-144
We investigated whether risk factors of coagulation in the circuit during continuous purification therapy (CBP) can be predicted from laboratory data. The subjects were 96 patients who underwent CBP at our hospital between November 2009 and August 2011. Coagulation in the circuit occurred within 24 hours on 7-day or longer treatment in an ER-ICU in 15 of the 96 patients. The total duration of treatment in 15 patients was 285 days. The daily data during the treatment period were subjected to multivariate analysis, and the risk factors influencing circuit coagulation were identified. The following 3 items were risk factors necessitating emergency exchange of the blood circuit: 25％ or lower Hct (HR: 3.189, 95％ CI: 1.606～6.335, P=0.0009), 350mg/dL or higher Fbg (HR: 4.266, 95％ CI: 1.082～16.826, P=0.0382), and 30μg/dL or higher FDP (HR: 3.077, 95％ CI: 1.275～7.425, P=0.011). The risk factors of coagulation in the circuit are increasing Fbg and FDP values and a lower Hct representing hypercoagulation. Circuit coagulation may occur in patients with a 25％ or lower Hct, 350mg/dL or higher Fbg, and 30μg/dL or higher FDP, for whom investigation of anticoagulants and consideration of the timing of circuit exchange are necessary.
