2013 Volume 4 Issue 1 Pages 87-92
Objective：To assess the effect of endotoxin adsorption therapy on patients with acute exacerbation of refractory drug-resistant interstitial pneumonia. Methods：Subjects were patients diagnosed with interstitial pneumonia whose respiratory failure was not ameliorated after steroid pulse therapy. Subjects were divided into two groups, treated or untreated with PMX-DHP, and statistical comparisons were performed between the two groups. Results：In the PMX group (n=11), compared with the non-PMX group (n=13), oxygenation (pre PMX vs. post PMX, P/F ratio：120.6＋/－43.5 vs. 183.6＋/－87.1, p＝0.044) and Week 4 prognosis (Kaplan-Meier method, logrank test, p=0.037) improved significantly. Conclusion：PMX-DHP can reverse serious acute respiratory failure in patients with acute exacerbation of drug-resistant interstitial pneumonia.
