Relationship Between recombinant thrombomodulin and obstruction of continuous blood purification circuit in disseminated intravascular coagulation cases

Abstract

【Objective】 The study aimed to examine the relationship between recombinant thrombomodulin (rTM) and obstruction of continuous blood purification (CBP) circuit in disseminated intravascular coagulation (DIC) cases. 【Method】 We compared the CBP circuit obstructive (within 24h) and non-obstructive group. and examined the relationship between the type of CBP circuit obstruction, patient characteristics, outcomes, and duration of patient’s stay in an ICU. 【Results】 The type of CBP circuit obstruction and patient characteristics or outcome did not significantly differ. Furthermore, the non-obstructive group required a significantly shorter period in the ICU than the obstructive group. The frequency of obstruction was intentionally low only with rTM use for a short. Moreover the difference was accepted by the rTM use existence without the patient characteristics and the duration of patient stay in the ICU. 【Conclusion】 Our result has suggested that rTM reduces the CBP circuit obstruction without changing the effect.