Retrospective analysis of association between prognosis and episodes of coagulation of polysulfone synthetic (PS) hemofilters in patients receiving continuous renal replacement therapy (CRRT)

Abstract

Using electronic medical record, the association between incidences of episodes of coagulation of PS hemofilters and severity and prognosis of patients receiving CRRT was retrospectively analyzed. The 171 patients who were treated with CRRT with PS hemofilter between March 2008 and September 2012 were divided into two groups: A, 80 patients who had at least more than one episode of coagulation during 24 hr of CRRT; and B, 91 patients who had no episode. There were no differences in the characteristics of patients and prescriptions for CRRT between the two groups. However, the sequential organ failure assessment (SOFA) score in group A was significantly higher than in group B (12.2＋2.7 vs. 10.8＋2.8; P＜0.05). Moreover, the mortality rate of patients in group A during hospitalization was greater than in group B (20 vs. 8; P＜0.05). These findings revealed that coagulation in PS filters in CRRT may be helpful as an indicator for prognosis of patients receiving CRRT.