Evaluation of a new weaning protocol from high-volume CHDF in patients with septic shock

Abstract

【Objective】We developed a tapering protocol from high-flow, high-volume CHDF in which dialysate and replacement flow rates was reduced gradually according to procedure intervals (tapering volume CHDF: TV-CHDF).【Patients and methods】Eight septic patients who received high-flow, high-volume CHDF for more than 72 hours consecutively in the past two years were enrolled in this study. Efficacy of TV-CHDF was assessed by changes in SOFA score, catecholamine dose and lactate level.【Results】SOFA score, catecholamine dose, and lactate level decreased with tapering of the amount of dialysate and replacement flow rates.【Conclusions】TV-CHDF resulted in improvement of septic shock and safety performance despite a time-dependent decline in removal efficacy of TV-CHDF. This TV-CHDF for treatment of septic shock may prevent unnecessary removal of essential substances in the blood and result in a favorable outcome.