Pharmacokinetics of teicoplanin in continuous renal replacement therapy with a polymethylmethacrylate membrane

Abstract

Teicoplanin (TEIC) is an antibiotic that require high-dose loading at the start of treatment. The effect of continuous renal replacement therapy (CRRT) with a polymethylmethacrylate (PMMA) membrane on TEIC serum concentration (TEICc) in a high-dose regimen has not been clarified. Hence, we investigated the change in TEICc in the high-dose regimen under CRRT with a PMMA membrane. Our results indicated that TEIC elimination with the PMMA membrane affected the TEICc. Under CRRT with a PMMA membrane, the high-dose regimen reached the target area of the TEICc early.