Does recombinant thrombomodulin therapy have any positive effect on patients with septic shock when combined with Polymyxin B immobilized fiber column direct hemoperfusion?

Abstract

【Objective】 We investigated the efficacies of recombinant thrombomodulin (rTM) during the Polymyxin B immobilized fiber column direct hemoperfusion (PMX-DHP). 【Method】 We retrospectively reviewed the medical records of patients who had been undergone PMX-DHP. All patients were divided into two groups: PMX-DHP with rTM, and PMX-DHP without rTM. The patient characteristics, outcomes, and changes of catecholamine needs, and platelets count were compared between two groups. 【Results】 There was no difference in the 28-day mortality between two groups. There was more decrease in catecholamine needs after the initiation of PMX-DHP in the group treated with rTM than the group without rTM. Although there was no statistical significance, the platelets count tended to recover when patients were treated with rTM. 【Conclusion】 In our study, rTM therapy combined with PMX-DHP showed no obvious positive effect on patients with septic shock. Further prospective study should be warranted to prove our hypothesis.