Clinical Comparative investigation on cytokine absorption removal and circuit interval pressure of polymethylmethacrylate hemofilters with different membrane surface area

Abstract

We investigated for cytokine absorption removal and circuit interval pressure of polymethymethacrylate (PMMA) membrane hemofilters with two different membrane surface area. We compared HEMOFEEL^® CH-1.0N(1.0m²) with HEMOFEEL^® CH-1.8W (1.8m²). Criteria for inclusion were patients who had surgery of generalized peritonitis with hypercytokinemia which IL-6 level is not less than 10,000pg/mL but not more than 100,000pg/mL at the start of continuous hemodiafiltration. It was analyzed from 11 cases using CH-1.0N and 9 cases using CH-1.8W. We made a comparative review of IL-6 level, inner circuit pressure, hemofilter life time, and 28 days survival rate at the beginning of the continuous hemodiafiltration, 6 hours later, 12 hours later, and 24 hours later. The data demonstrated that IL-6 level with the use of CH-1.8W increased to 1.3 times.