2015 Volume 6 Issue 2 Pages 140-144
We evaluated the interleukin (IL)-6 adsorption ability of the polymethyl methacrylate (PMMA) hemofilter “Hemofeel CH-1.8W” (Toray Industries, Inc.), which has been used clinically since October 2013. 【Subjects】 We assessed 10 patients who received continuous renal replacement therapy (CRRT) with Hemofeel CH-1.8W whose IL-6 levels were ＞1,000pg/mL at 15min after the start of CRRT. 【Methods】 We measured IL-6 clearance at 15min, 1h, 24h and 48h after therapy commencement. 【Results】 Mean IL-6 clearance (mL/min) was 41.95±7.70 at 15min, 21.50±10.11 at 1h, 8.67±2.67 at 24h, and 13.34±16.77 at 48h. 【Conclusions】 IL-6 clearance was reduced significantly at 24h and 48h. These data suggest that the filter should be changed every 24h to keep its high adsorption performance.
