Treatment of severe acute pancreatitis using continuous hemodialysis with high flow-volume large size polymethylmethacrylate-hemodiafiltration

Abstract

Continuous hemopurification therapy using a polymethylmethacrylate (PMMA) hemofilter has proved to be effective for the treatment of severe acute pancreatitis (SAP). Between January 2011 and December 2015, 20 patients with SAP were treated with continuous hemodialysis using a PMMA hemofilter (PMMA-CHD). Additional high flow-volume large size PMMA-hemodiafiltration (PMMA-HDF) was performed for six of these patients. Here we present the case of two of six patients. Among the 20 patients, all but one recovered from SAP. These results demonstrated that high flow-volume large size PMMA-HDF improves lung injury and severe complications of SAP through its ability to regulate cytokines.