Abstract
Autism spectrum disorder (ASD) is recognized as one of the major neuropsychiatric disorders defined as social deficits, repetitive behavior and lack of communication skills. Since the word “spectrum” means “a condition that is not restricted to a specific set of values but can vary, without steps, across a continuum”, patients with ASD showed broad and various phenotypes. Although the past bulk RNAseq studies have succeeded to identify converged pathways, genes, and networks in ASD, these outcomes may reflect the results of major cell‐type alternation but not in minor cell‐type one. Here we introduce a recent technique, single cell RNA‐sequence (scRNA‐seq) , which enables to analyze at a single‐cell resolution. The scRNA‐seq sheds light on minor cell‐types that may be an important factor for ASD pathogenesis. The single cell analysis with bioinformatics, combined with genome editing tools, will become a key player to understand heterogeneous psychiatric disorders, such as ASD.
