Abstract
Current advances of single‐cell resolution analyses such as “single‐cell RNA sequencing (scRNA‐seq) ”, followed by chromatin structure (chromatin accessibility) analysis by “ATAC‐seq”, cell membrane (surface) protein analysis by “CITE‐seq”, and “gene expression analysis with spatial gene expression information on the tissue sections” enable us to realize multimodal omics analysis for neurodevelopmental and neuropsychiatric disorders. Combined with other methods such as 3D brain organoids, these techniques have discovered a better understanding of in vivo gene functions and pathophysiology of human brain diseases. These techniques have been explained the previously unknown molecular and cellular‐specific mechanism of neuropsychiatric and neurodevelopmental disorders. In this review, we introduce the latest findings of autism spectrum disorder (autism) and novel coronavirus infection (COVID‐19) from the single‐cell analysis.
