抄録
3', 5'-Cyclic AMP (cyclic AMP)-dependent and independent protein kinases (protein kinase B1 and B2, respectively) and a cyclic AMP-binding protein (R-protein) are partially purified from rat liver. Although R-protein shows no kinase activity, it almost totally depresses protein kinase B2 activity. Cyclic AMP relieves the kinase of the inhibition by R-protein. The treatment of protein kinase B1 with cyclic AMP resolves the kinase into R-protein and protein kinase B2. The evidence indicates that protein kinase B1 is a complex of R-protein and protein kinase B2, and that cyclic AMP may regulate the attachment of R-protein to the protein kinase.
