抄録
Non steroidal anti-inflammatory drugs generally act as an uncoupler on oxidative phosphorylation. And many reports also have shown that non-steroidal anti-inflammatory drugs have the capacity of lysosomal membrane stabilization. The present authors tried to examine this stabilization by the drug by using rat liver and agarplanted granuloma. The results showed that anti-inflammatory non-steroidal drugs had effects of either stabilization or disruption of lysosomal membranes. These two effects depend on the concentration of drug used. Based upon these results, the authors present a schema which explains the inflammatory process from the biochemical viewpoint.
