抄録
In our previous paper, we reported that 13-18% of dipropyl acetate (DPA), a new anticonvulsant drug, was excreted in expiratory air during 24 hour afters oral administration. We have since studied the degradative pathway of DPA by means of gas chromatography and gas chromatography-mass spectrometry.
Twenty four hour urine specimens of Wister male rats after oral administration of DPA were extracted with ethyl acetate and ethyl ether, combined and concentrated in vacuo, and trimethylsilylated with bis-(trimethylsilyl)-acetamide and trimethylchlorosilane for gas chromatography and gas chromatography-mass spectrometry. Six peaks characteristic of the DPA-treated rats were detected by gas chromatography, and the compounds were identified by gas chromatography-mass spectrometry. Peaks 1 and 2 were thus shown to represent DPA and succinic acid, and peaks 4 and 6 were the oxidation products of DPA and identified as ω-hydroxy dipropyl acetate and ω-carboxy dipropyl acetate, respectively.
Thus it is established that DPA is metabolized by ω-oxidation to ω-carboxy dipropylacetate. In addition, it is also probable that DPA is degradated by β-oxida tion.
