抄録
Apo C II and C III of serum VLDL were determined in various types of hyperlipidemias by isoelectric focusing of polyacrylamide gel plate with a pH gradient 4.0-6.0. VLDL from hyperlipidemias of type lib, III, IV and hypo α-lipoproteinemia had high C II/C III ratio. Percentage of apo C III-O tended to increase in type III and IV, and decreased in type lla and hypo α-lipoproteinemia. Therefore, apo C ll/C III-O was not changed in type III, IV and V and increased type II a and hypo α-lipoproteinemia. Apo C III-1 did not change in every type of hyperlipidemias when compared with normolipidemic control but apo CIII-2 decreasedin type II b and IV. Decrease of apo C III-2 and increase of apo C III-O in hypertriglyceridemic patients suggests the relative impairment of sialylation of apo C III proteins.E/C ratio was low in type II b, IV and hypo α-lipoproteinemia.
There were no clear relationship between C II/C III or C II/C III-O ratio and serum triglyceride or pre β-lipoprotein concentration. It is concluded that apo C composition of VLDL is not always related to the development of hypertriglyceridemia.
