Studies on the Changes of High Density Lipoprotein in Hypertriglyceridemias

Abstract

Serum high density lipoprotein (HDL) fractions of various hyperlipidemic patients were separated by polyanion methodand ultracentrifugation, then their lipid compositions and apolipoprotein A (apo A) were analyzed.
HDL cholesterol of hypertriglyceridemic patients were significantly lower than those of normolipidemic subjects.On the other hand, apo A in HDL of Type IIb patients were not different from those of normotriglyceridemias.Also in other types of hypertriglyceridemias, apo A in HD were not significantly lower.
The ratios of apo A/total cholesterol and apo A/esterified cholesterol in HDL from hypertriglyceridemias were higher than those from normotriglyceridemias and the ratios of apo A/triglyceride in HDL from hypertriglyceridemias were lower.Decrease of cholesterol and increase of triglyceride were observed in HDL fractions from hypertriglyceridemias and hypo α-ipoproteinemias.
Correlation coefficient between HDL concentration and HDI apo A was better than that between HDL and HDL cholesterol.
VLDL fraction was increased significantlay nd HDL fraction was decreased in Triton induced hypertriglyceridemic rats and similar compositional change of HDL (the relative increase of triglyceride and decrease of esterified cholesterol) Was observed.
From the results of analysis of apoprotein in HDL and VLDL from Triton injected rats by isoelectric focuslng, it was shown that apo C in VLDL was significantly increased and apo C in HDL was decreased.