Effect of an Oral Elastase Preparation (Elaszyme) on the Flastase Activity and Lipid Levels in Blood

Abstract

An oral elastase preparation (Elaszyme, Eisai Co., porcine pancreatic) was administered to 42 patients with hyperlipemia having more than 220mg/dl of total cholesterol and more than 120 mg/dl of triglycerides.
Although oral enzyme preparation may be poorly absorbed into the blood stream, serum elastase activity, on suc (Ala) 3pNA, 14C-elastin and autoclave treated natural elastin, showed an increasing tendency by the administration of the preparation.Significantly higher serum levels of total cholesterol, triglycerides, phospholipids, ζ-lipoproteins and lipid peroxides were lowered to the extent of the normal levels, and such normalizing tendency was more remarkable when these levels were considerbly higher before the administration of the preparation.