Changes in Serum Metal Levels after a Single Hemodialysis Treatment of the Patients of Chronic Renal Failure with Long-Term Hemodialysis

抄録

When patients with chronic renal failure were treated with long-term hemodialysis, serum cadmium and lead levels were increased and chromium was decreased. The change in serum metal levels after a single treatment of hemodialysis was measured. The results are as follows: 1) Serum cadmium and lead values increased during a single hemodialysis but the levels per serum protein were unchanged. The change in serum cadmium and lead levels during the treatment depended on each metal concentration in dialyzing fluid. 2) When the dialyzing fluid was sampled periodically, cadmium and lead levels in the dialyzing fluid were shown to decrease throughout the treatment. These results show that serum cadmium and lead do not flow from the dialyzing fluid into the blood, but rather from the blood to the dialyzing fluid.
3) The chromium levels and chromium per protein ratio in serum tended to decrease during a single hemodialysis treatment. The chromium level in the dialyzing fluid increased after treatment, peaking 1 hour after the treatment. It is hypothesized that chromium was excreted from the serum to the dialyzing fluid. Serum chromium levels in the patients with the long-term hemodialysis treatment were similar to that in diabetic patients. Therefore, it is supposed that the metal levels in the dialyzing fluid control the serum metal levels and that cadmium and lead accumulate in the patients undergoing long-term ihemodialysis causing toxic symptoms.