Abstract
Plasma protein, αl-acid glycoprotein from patients with various urogenital diseases, including renal cancer, acute pyelonephritis and urolithiasis, was resolved by highperformance liquid chromatography (HPLC) using an anion-exchange column. Before the HPLC the plasma was pretreated by Blue-Sepharosoer Con A-Sepharose affinity chromatography. The peak of the α1-globulin fraction containing αl-acid glycoprotein was high in patients with advanced neoplastic or acute inflammatory disease, but not in patients with non-inflammatorby enign disease. The DNA synthetic activity of normal peripheral blood lymphocytes in vitro was suppressd more by the αl-globulin fraction prepared by HPLC from patients with neoplastic disease than by that from patients with non-inflammatory benign disease.
