High Density Lipoproteins in the Patients with High Serum Amyloid A Proteins

Abstract

Serum high density lipoprotein (HDL) a nd amyloid protein A (SAA) i n HDLw ere analyzed using ultracentrifugation and isoelectrofocusing in patients with high C-reactive protein (CRP) levels but no serious hepatic and renal insufficiencies, malnutritions, endocrine disorders and hyperlipidemias.
It was indicated that SAA percent of the total HDL proteins or the estimated SAA concentrations in HDL were well correlated with CRP concentrations in various kinds of diseases at acute phase.
The serum HDL and their apo A and C protein concentrations were lower in the CRPpositive patients than in the CRP-negatives, but apo E protein concentration of the former was not different from that of the latter. Although apo A-I /A-II and A-I /C ratios were identical in both groups, A-I /E ratio was low in the SAA-rich HDL. It suggests that such HDL is relatively rich in apo E protein. However, the protein-lipid compositions in HDL were not different significantly between the two groups.