Abstract
Free radicals (superoxide or hydroxyl radical) play an important role in the pathogenesis of gastric mucosal lesions after ischemia and administration of diethlyldithiocarbamate. Some antiulceratives, have been reported to trap hydroxyl radicals and some have been reported to protect against lipid hydroperoxidation. However, whether these antiulceratives have a direct superoxide scavenging activity has been unknown. Therefore, we examined the superoxide scavenging activities of many antiulceratives in the present experimental systems.
We found that plaunotol, benexate, rebamipide, sofalcone and MMSC (methylmethioninesulfonium chloride) have superoxide scavenging activities.
