Distribution of the LDL Subclasses and Apolipoprotein Levels in Hyperlipidemias

Abstract

LDL subclasses were determined by nondenaturing polyacrylamide slab gel electrophoresis in sera from normal and hyperlipidemic subjects (IIa, IIb and IV) and their size distributions were examined with reference to the levels of apolipoproteins. Apolipoproteins B, C-II, C-III and E were significantly high in sera from hyperlipidemic patients, while there was no significant difference in the level of apolipoprotein A-I. The smaller LDL subclasses (Rf = 0.80, 0.84, 0.92) appeared in hyperlipidemic patients but not in normal subjects. Smaller LDL subclasses showed increased prevalence among patients with hyperapolipoproteinemia and tended to be increased among patients with vascular complications; cerebral infarction, myocardial infarction, hypertension and diabetes mellitus with complications.