Urinary Excretion of Norepinephrine and Dopamine in Normal Subjects

抄録

Norepinephrine (NE) and dopamine (DM) in night and daytime urine of normal subjects (n=45 for men and n=22 for women) were measured simultaneously by the fluorescamine method using HPLC. The excretion rates of NE in the nitghttime were 14.1±6.9 ng/min for men and 11.1±6.5 ng/min for women without sex difference. The values in the daytime were two or three times as high as those in the nighttime. Men excreted more DM in the daytime than in the night while women excreted less DM in the daytime. The excretion rates of DM in the nighttime were 181.0±94.4 ng/min for men and 166.3±70.9 ng/min for women, which correlated well with those of creatinine (γ=0.671 for nighttime and 0.797 for daytime). The nighttime urine was found to be useful for the clinical diagnosis.