2016 Volume 39 Issue 5 Pages 455-459
In the pathogenesis of rheumatoid arthritis (RA), TNFα and IL-6 are proved to be crucial cytokines. Monocyte and macrophage are thought to produce these cytokines, as well as the source of cells becoming osteoclast in RA. In this review, I will discuss the role of monocyte/macrophage and the recent topic of negative regulator of arthritis such as TNFα-induced adipose related protein in RA.