Abstract
It is well known that both pernicious anemia and Hashimoto's thyroiditis are organspecific autoimmune disease, and that both sometimes co-exist each other. Now, we experienced a 54-year-old woman complicated with both disease. She complained of general malaise, and she had white hair, an atrophy of lingual papilla, thyroid struma (grade III, elastic hard) and slight disturbance of sensation. Laboratory data was that RBC 1.36×106, MCV 131 fl, vitamin B12 44.9pg/dl in the peripheral blood, and NCC 2.8×105 and megaerythroblast 15.2% in the bone marrow. Another was that Schilling's test, anti-microsome antibody (Ab), anti-parietal cell Ab and anti-intrinsic factor Ab were positive, but anti-thyroglobulin Ab was negative. These thyrogastric autoimmune diseases are popular in Europe and North America, but they are rare in Japan. The published reports on thyrogastric autoimmune disease are only 26 cases in Japan including our case. The majority of patient is female and the average age is 52.2years old. In 12 cases, patients first suffered from Hashimoto's thyroiditis, and ones did from both disease on almost same time in 9 cases. It is very interesting why some autoimmune disease tend to cluster. So, we described some fact and speculation about the relationship of pernicious anemia and Hashimoto's thyroiditis. And we discussed the reason why two organ-specific autoimmune disease associated each other, i. e. pernicious anemia and Hashimoto's thyroiditis.
