Abstract
A case of primary biliary cirrhosis associated with Sjögren's syndrome, CRST syndrome and eary gastric cancer was reported. A 73-year-old female has been suffered from Raynaud's phenomenon, sclerodactyly, arthralgia and Sicca syndrome. She was diagnosed as Sjögren syndrome and CRST syndrome with her additional symptoms of calcinosis and telangiectasia. The specimen of liver taken of the occasion of gastrectomy of her stomach for early gastric cancer (Type IIc, moderately differrentiated adenocarcinoma) showed a histology of primary biliary cirrhosis showing chronic non supprative destructive cholangitis with mononuclear cell infiltration in Glisson's sheath followed by granuloma. The titers of anti-mitochondria, anti-DNA antibody and eosinophilia decreased during the period of observation. However, the intensity of PPD reaction and PHA stimulation test was unchanged. Her HLA showed DR 4 and DR 9. It was suggested that CRST syndrome, PBC and eary gastric cancer might related to the immunological abnormality in broad spectrum observed in Sjögren's syndrome.
