Abstract
A study was performed on the enterobacterial flora and secretory IgA concentration in feces of the cases, in which diarrhea occurred during the administration of antibiotics. In the cases, where clostridium difficile and its toxin were detected in feces, total number of bacteria in feces and secretory IgA concentration decreased and the enterobacterial flora was destroyed. In the enterobacterial flora of these cases, anaerobic bacteria such as Bifidobacterium, Bacteroides, Eubacterium, etc. decreased, while yeast increasd. In some of these cases, Streptococcus and Lactobacillus have also increased. In the cases, in which Cl. perfringens and Cl. butyricum were detected in feces, Cl. difficile was not found. In the cases, in which Cl. difficile was detected and to which Cl. butyricum preparation has been given perorally, the number of Cl. difficile was lower than the cases, to which Cl. butyricum preparation was not given, and the production of toxin was also low.
