Abstract
We report a case of Weber-Christian disease who showed hypothermia after treatment with prednisolone. A 12-year-old female was admitted to our hospital because of remittent fever and subcutaneous nodules with pain. She failed to respond to treatment with antibiotics and aspirin. The histological findings in skin biopsy revealed acute panniculits with vasculitis. The diagnosis of Weber-Christian disease suggested by clinical features was confirmed. Prednisolone at initial dosage of 40mg per day was used for therapy. Fifteen hours after prednisolone therapy was begun, her temperature dropped rapidly to 34.1°C. The temperature ranged between 34.2°C to 36.0°C for 40 hours and then rose slowly over the next 3 days. The other clinical symptoms and laboratory data improved by prednisolone therapy. This case was interesting in to consider the effect of adrenocorticosteroid to the thermo-regulation.
