Abstract
A patient of chronic fatigue syndrome (CFS) with low CD4/CD8 was reported. A 23-year-old male was admitted to our hospital because of low grade fever and general fatigue. Besides, the patient complained of sore throat, myalgias, muscle weakness, headaches which lasted for a long time. Infectious disease, connective tissue disease, and malignancy were ruled out. Based on the clinical criteria proposed by CDC criteria, he was diagnosed CFS. In addition, low CD4/CD8 ratio and lymulus lysate test positivity were persisted for a long time. These findings suggested that CFS was based on a kind of immunological disorder.