Membranoproliferative glomerulonephritis in Wiskott-Aldrich syndrome: improvement by alternative day methylprednisolone therapy

Abstract

This report presents a 2-year-old boy with Wiskott-Aldrich syndrome, who developed membranoproliferative glomerulonephritis. The patient presented microhematuria, prote-inuria and hypertension at one year old when the patient developed recurrent episodes of respiratory infection. A histological study on the renal biopsy specimen revealed a diffuse and global double contour lesion in the capillary wall by light microscopy, but C 3 deposits were not recognized by immunofluorescent study.
There have been reports of nephropathy development in some patients with Wiskott-Aldrich syndrome after treatment with a transfer factor; however, our patient developed renal disease without the use of a transfer factor. The patient improved with methylpred-nisolone, at an alternate day regimen. This case provides valuable information of the clinical features of renal involvement in the course of Wiskott-Aldrich syndrome especially in relation to recurrent respiratory infections.