Granulocyte-colony stimulating factor producing esophageal cancer: report of a case and review of the literature

Abstract

Our case described a 62-year old male patient diagnosed as esophageal cancer with production of granulocyte colony-stimulating factor (G-CSF). A peripheral blood analysis revealed granulocytosis of 35, 400/mm³ although he did not have any infections, hematological disorders or metastasis of cancer. Serological analysis of G-CSF was not detected, though high concentration of G-CSF was determined in culture supernatant of carcinoma tissue resected from the esophagus. After total resection of cancer, the number of granulocyte normalized. Only one case of esophageal cancer suspected of G-CSF production has been reported, but there was no evidence that the cancer produced G-CSF. In this case, the production of G-CSF from esophageal cancer was demonstrated using monoclonal anti G-CSF antibodies in the enzyme linked immunoadsorbent assay.