1993 Volume 16 Issue 5 Pages 397-402
A case of lupus erythematosus profundus (LEP) which was improved by betamethasone was reported. A 47-year-old female admitted to our hospital with chief complaints of erythematosus skin lesions and subcutaneous nodules on the right cheek and chest. Light microscopic features of skin lesions were consistent with LEP, resulting from the dilatation of small vessels in the dermal layer, the infiltration of mononuclear cells mainly lymphocytes around the vessels and at the septum of subcutaneous tissue. Immunofluorescence staining revealed deposits of immunoglobulin at the epidermal-dermal junction. This finding supported the diagnosis of LEP and the patient improved remarkably by the administration of 1.25mg/day of betamethasone. From the review of previous literatures, the clinical and diagnosis of LEP are discussed.
