Abstract
Anti-idiotypic (Id) antibody activity to auto and allo anti-DNA antibody in sera of 10 patients with systemic lupus erythematosus (SLE) was studied. Anti-Id antibody activity to auto anti-DNA antibody was detected in inactive phase of all cases, and it was suggested that anti-Id antibody to auto anti-DNA antibody might be closely related to the disease activity and immune regulatory system. Anti-Id antibody activity to allo anti-DNA antibody and monoclonal anti-ds DNA antibody (NE-1) was highly detected in inactive phase. We thought that the cross reactive Id may be and a restricted number of Id exists among anti-DNA antibody in sera of SLE patients.
