The expression of lymphocyte function associated antigen-1, intercellular adhesion molecule-1 on peripheral blood lymphocytes in patients with systemic lupus erythematosus

Abstract

The ratios of CD 11 a, CD 18, HLA-DP on T cells and CD 54 on B cells of 54 patients with active systemic lupus erythematosus (SLE) were examined. The ratios of LFA-1 α, β, ICAM-1, HLA-DP among SLE patients were significantly higher when compared with normal healthy controls, and the significant correlation between the ratio of LFA-1⁺ T cells and HLA-DP⁺ T cells, and LFA-1⁺ T cells and ICAM-1⁺ B cells was recognized.
These results may suggest that LFA-1, ICAM-1 is related to the mutual action between activated T cells and B cells.