Effective treatment of autoimmune diseases with extremely low dose cyclosporine

Motonobu Sugiyama; Iwao Sekigawa; Yoshiaki Tokano; Noboru Iida; Hiroshi Hashimoto; Shun-ichi Hirose

doi:10.2177/jsci.21.20

Motonobu Sugiyama, Iwao Sekigawa, Yoshiaki Tokano, Noboru Iida, Hiroshi Hashimoto, Shun-ichi Hirose

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Keywords: cyclosporine, thrombocytopenia, interstitial pneumonitis, systemic lupus erythematosus, Sjögren's syndrome

JOURNAL FREE ACCESS

1998 Volume 21 Issue 1 Pages 20-28

DOI https://doi.org/10.2177/jsci.21.20

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Abstract

The dosage of cyclosporine administered in the treatment of autoimmune diseases has generally been comparable to those required in cases of transplantation. Here we report on the successful treatment using an extremely low dose cyclosporine (1mg/kg/day) on four patients, involving thrombocytopenia with systemic lupus erythematosus, and interstitial pneumonitis with Sjögren's syndrome, and discuss the optimal dose of cyclosporine for autoimmune-mediated manifestations.

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