Partial splenic embolization for idiopathic thrombocytopenic purpura

Toshiaki Hayashi; Nobuaki Sugawara; Tohru Takahashi; Yasushi Adachi; Yusuke Makiguchi; Hiroki Takahashi; Masaaki Adachi; Yuji Hinoda; Kazuhiro Yamashiro; Mitsuhiro Mukaiya; Tadashi Katsuramaki; Koichi Hirata; Kohzoh Imai

doi:10.2177/jsci.21.29

Toshiaki Hayashi, Nobuaki Sugawara, Tohru Takahashi, Yasushi Adachi, Yusuke Makiguchi, Hiroki Takahashi, Masaaki Adachi, Yuji Hinoda, Kazuhiro Yamashiro, Mitsuhiro Mukaiya, Tadashi Katsuramaki, Koichi Hirata, Kohzoh Imai

Author information

Toshiaki Hayashi
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Nobuaki Sugawara
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Tohru Takahashi
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Yasushi Adachi
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Yusuke Makiguchi
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Hiroki Takahashi
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Masaaki Adachi
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Yuji Hinoda
First Department of Internal Medicine, Sapporo Medical University School of Medicine
Kazuhiro Yamashiro
First Department of surgery, Sapporo Medical University School of Medicine
Mitsuhiro Mukaiya
First Department of surgery, Sapporo Medical University School of Medicine
Tadashi Katsuramaki
First Department of surgery, Sapporo Medical University School of Medicine
Koichi Hirata
First Department of surgery, Sapporo Medical University School of Medicine
Kohzoh Imai
First Department of Internal Medicine, Sapporo Medical University School of Medicine

Keywords: idiopathic thrombocytopenic purpura, partial splenic embolization, splenectomy, high dose intravenous immune globulin, PAIgG

JOURNAL FREE ACCESS

1998 Volume 21 Issue 1 Pages 29-32

DOI https://doi.org/10.2177/jsci.21.29

Details

Abstract

Twelve patients with idiopathic thrombocytopenic purpura (ITP) who were resistant to conventional steroid therapy under went partial splenic embolization (PSE). PSE was effective for 7 out of 10 eligible cases. The reduction ratio of PAIgG was significantly higher in effective cases. The PAIgG level before treatment and platelet counts one week after PSE were higher in effective cases than those of non-effective cases. The effects of PSE did not depent on age, sex, the duration of disease, platelet count, embolization rate or the effect of intravenous immunoglobulin therapy. No serious side effects were observed. PSE can be an alternative therapy to splenectomy for ITP.

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