Japanese Journal of Clinical Immunology
Online ISSN : 1349-7413
Print ISSN : 0911-4300
ISSN-L : 0911-4300
Effect of streptococcal preparation, OK-432 on cultured spontaneous cell mediated cytotoxicity (CSCMC) and Ig production in vitro
Fumio KawanoHirokazu FujiwaraHiromitsu MatsuzakiShinhachiro TominoHiroaki MitsuyaKoichi ArakiSusumu Kishimoto
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1981 Volume 4 Issue 6 Pages 312-321

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Abstract
The effect of the steptoccocal preparation OK-432 on the in vitro immune responses by the human periperal blood lymphocytes was studied.
The results obtained were as follows.
1) OK-432 did not enhance natural killer (NK) cell activity.
2) OK-432 enhanced cultured spontaneous cell mediated cytotoxicity (CSCMC). The most enhancing effect is at a concentration of around 10-3 KE/ml and is recognized as statistically significant at the cultured duration of 3, 5 and 7 days.
The activity of CSCMC was most remarkable in the cell fraction which was not adherent to nylon wool and not rosetted with En.
However, some of En-rosette-forming cells also had a little activity.
3) OK-432 induced much more Ig production by B cell than did PWM.
4) OK-432 stimulated DNA synthesis of lymphocytes.
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© The Japan Society for Clinical Immunology
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