Treatment of carcinomatous peritonitis and pleuritis by i. p. injection of OK-432 with fresh frozen plasma

Arachidonic acid metabolites and neutrophil chemotaxis

Abstract

Anti-tumor effect of neutrophil migrating into peritoneal or pleural cavity was demonstrated in patients with carcinomatous peritonitis or pleuritis by the intraperitoneal or intrapleural injection of OK-432. Complement-derived chemotactic factor such as C 5a might play a role to attract neutrophil into the cavity, when patients received i. p. injection of OK 432 with fresh frozen plasma as a sourse of complement. Increased levels of thromboxane B₂ and leukotriene B₄ as well as C 5a were found before neutrophil attracted in the fluids. These results suggested that arachidonic acid metabolites participated in the migration of neutrophil.