特集／病院情報標準ストレージ(SS-MIX)の市販後の調査および臨床試験への応用
4．PPIを題材にしたこれまでの研究報告
2013 年 44 巻 3 号 p. 263-265
詳細
2013 年 44 巻 3 号 p. 263-265
We have studied and reported the influences of CYP2C19 polymorphism on the clinical efficacy of proton pump inhibitors(PPI), such as acid inhibition and cure rates of H.pylori infection and gastroesophageal reflux diseases(GERD) by PPI-based regimens. We linked the SS-MIX information and CYP2C19 genotypes on the computer disconnected to anything else and found that dose of PPI depended on CYP2C19 genotypes in patients with GERD. We studied the effect of CYP2C19 polymorphisms on the symptomatic recurrences of GERD in patients treated with a low dose of a PPI. We found that patients with rapid metabolizer genotypes of CYP2C19 had a higher risk of symptomatic recurrence of GERD when treated with a low dose of a PPI. (Jpn J Clin Pharmacol Ther 2013; 44(3): 263-265)
