血液透析下におけるダルベポエチン アルファ注射液 5 μg 単回静脈内投与時の薬物動態

抄録

The present study investigated the pharmacokinetics of darbepoetin alfa (DA) after a single intravenous injection of 5 μg in 6 patients on hemodialysis. Following a washout period of erythropoiesis stimulating agents (ESA), DA at 5 μg was injected intravenously after the first dialysis session of the week. Serum concentrations of DA were measured at 8 points: before and 0.5 to 168 h after DA dosing. Serum concentrations of DA ranged from 1.9 to 3.4 ng/mL at 0.5 h, and was maintained at almost 1 ng/mL even at 24 h after DA dosing. The elimination half-life, AUC_0−∞ and V₀ were calculated as follows (mean±SD): 21.2±6.2 h, 68.3±10.5 ng・h/mL and 2280±770 mL, respectively. The serum concentration-time profile showed similarity with those after single intravenous injection of DA at 10 to 60 μg. Considering the serum concentrations of DA required to stimulate erythropoiesis in erythroid progenitor cells, intravenous injection of DA at a dose of 5 μg is expected to be suitable for achieving effective serum DA concentration in patients on hemodialysis with renal anemia.