Clinical Efficacy of Furosemide-Retard (Hoe 058 R) in Essential Hypertension ADouble-Blind Controlled Study with Trichlormethiazide

Teiryo MAEDA; Yoshiaki MASUYAMA; Shozo KOSHIKAWA; Teizo SANJYO; Akio EBIHARA; Tsuneji NAGAI; Teizo ITO; Takao IKEDA; Masashi ISHIDA; Tadashi ITOKAWA; Keizo KOIDE; Tetsugo SAKATA; Takuo SASAOKA; Masayoshi SHIBAGAKI; Toshiro SHIBATA; Katsutaka SETA; Sho TANAKA; Masao TAKAHASHI; Toshio HARADA; Saburo HIDAKA; Ippei FUJIMORI; Yo YAMAGATA; Yoshiji YAMANE; Osamu YOKOTA

doi:10.3999/jscpt.10.425

本態性高血圧症に対する持効性Furosemide (Hoe058R) の臨床効果

二重盲検法によるTrichlormethiazideとの比較試験成績

前田貞亮, 増山善明, 越川昭三, 三条貞三, 海老原昭夫, 永井恒司, 伊東貞三, 池田隆夫, 石田尚志, 糸川正, 小出桂三, 坂田徹吾, 笹岡拓雄, 柴恒昌功, 柴田俊郎, 瀬田克孝, 田中政, 高橋政夫, 原田敏雄, 日高三郎, 藤森一平, 山形陽, 山根至二, 横田修

著者情報

前田貞亮
関東労災病院内科
増山善明
Dept. of Circulation, Wakayama Medical College
越川昭三
Dept. of Internal Medicine, Fujigaoka Hospital of Showa University
三条貞三
Dept. of Internal Medicine, Tokyo Teishin Hospital
海老原昭夫
Dept. of Clinical Pharmacology, School of Medicine, Jichi Medical School
永井恒司
Dept. of Pharmacy, Hoshi Pharmaceutical College
伊東貞三
Dept. of Circulation, Self-Defense Forces Central Hospital
池田隆夫
Dept. of Internol Medicine, Kanto Teishin Hospital
石田尚志
1st. Dept. of Internal Medicine, St. Marianna Ika Daigaku
糸川正
2nd. Dept. of Internal Medicine, School of Medicine, Showa University
小出桂三
Dept. of Circulation, National Oji Hospital
坂田徹吾
Dept. of Internal Medicine, Tokyo Rosai Hospital
笹岡拓雄
Dept. of Internal Medicine, Yokosuka Kyosai Hospital
柴恒昌功
Dept. of Internal Medicine, Kawasaki Municipal Ida Hospital
柴田俊郎
Dept. of Internal Medicine, Hitachi Seisakusho Totsuka Hospital
瀬田克孝
Dept. of Internal Medicine, Central Hospital of Health Insurance
田中政
2nd. Dept. of Circulation, Japanese Red Cross Medical Center
高橋政夫
Dept. of Internal Medicine, Omori Red Cross Hospital
原田敏雄
Dept. of Internal Medicine, Kodaira Memorial Hitachi Hospital
日高三郎
Dept. of Internal Medicine, Kawakita Hospital
藤森一平
Dept. of Internal Medicine, Kawasaki Municipal City Kawasaki Hospital
山形陽
Dept. of Nephrology, Hitachi General Hospital
山根至二
Dept. of Internal Medicine, Tokyo Kosei Nenkin Hospital
横田修
Dept. of Internal Medicine, Omiya Red Cross Hospital

ジャーナルフリー

1979 年 10 巻 3 号 p. 425-447

DOI https://doi.org/10.3999/jscpt.10.425

詳細

抄録

The antihypertensive effect and usefulness of Hos 058 R (H) were compared with those of trichlormethiazide (T) as a control drug under double-blind conditions.
The following results were obtained.
1. Antihypertensive effect
There was no significant difference between Hoe 058 R and trichlormethiazide in the global evaluation of antihypertensive effect. The effects on both systolic and mean blood pressure were significantly greater with T than with II However, there was no significant difference in the effect on diastolic pressure.
2. Laboratory data
The decrease in the serum Cl- level in 8th week was significantly greater in the T-group than in the H-group.The BUN elevation in the T-group was significantly higher than in the H-group.
3. Side effects
The incidence of pollakiuria and polyuria was 7.1% (6/85) in the H-group and 3.7% (3/82) in the T-group.This difference was not significant. No other note-worthy side effects occurred.
4. Usefulness
There was no significant difference between the two groups.

責任著者(Corresponding author)

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