抄録
The pharmacokinetics of amikacin (4 mg/kg) was studied in healthy volunteers (n=5) by inravenous drip infusion and intramuscular injection. After intravenous infusion for 1 hr, the antibiotic followed a two compartment model, and after intramuscular injection it followed a one compartment model.
Concentrations of amikacin were assayed microbiologically, radioimmunologically and radioenzymatically. After intravenous infusion the maximum concentration (Cmax) was obtained at the end of infusion and was higher than that obtained at 45 min after intramuscular administration. The route of administration did not significantly modify the pharmacokinetic parameters of amikacin except Cmax and the time obtained Cmax (Tmax). Urinary excretion was slightly higher in intravenous infusion than that in intramuscular administration. There were good correlations among three different assays of amikacin concentration.
The serum concentrations of amikacin in repeated intravenous drip infusion twice a day werecoincided with concentrations simulated using pharmacokinetic parameters obtained by single administration.
Decreased renal excretion of amikacin was observed in bedridden elderly patients.
