Abstract
Diuretic and uricosuric effects of traxanox sodium (TRX, 180 mg three times daily for 8 days) were investigated by double blind, cross over comparison with hydro chlorothiazide (HCT, 25 mg twice daily for 8 days).
Urine volume and urinary excretion of electrolytes increased after the administration of TRX. Asimilar trend was observed on HCT. The urinary excretion of uric acid increased and serum concentration of uric acid decreased on TRX. However, the urinary excreti on of uric acid decreased and serum concentration of uric acid in creased on HCT.
Serum Na, K and Cl decreased, while serum Ca and PRA increased on HCT, while only serum Cl decreased on TRX. Neither drug induced any significant changes in blood pressure, pulse rate, body temperature or body weight.
These results show that TRX has a uricosuric effect in humans.
