Studies on Transdermal Absorption of Isosorbide Dinitrate Tape

Abstract

With the object of obtaining information about factors influencing the effect of isosorbide dinitrate (ISDN) tape (Frandol tape®), the effect of bathing, application site, water content of the corneal layer of epidermis, tissue blood flow and age on the plasma ISDN concentration was studied by applying Frandol tape® to healthy male volunteers, and the following results were obtained.
1. The plasma ISDN concentration was enhanced transiently upon bathing.
2. A higher plasma ISDN concentration was obtained when the tape was applied on the back or leg than on the breast.
3. There was no relationship between plasma ISDN concentration and water content of the corneal layer or on the tissue blood flow.
4. High plasma ISDN concentrations were exhibited in younig men, but were not Significant.