抄録
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigatedin healthy subjects following single oral doses of 10, 30, 60, and 120mg. For 30, 60, and 120mg, 5 subjects were studied for each dose ; for 10 mg, only 2 subjects were studied.Plasma and urine Cepharanthin levels were measured by the HPLC method and wereanalyzed by the one-compartment open model. Linear relationships were obtained betweenthe dose from 10 to 120mg of Cepharanthin and the Cmax or the AUC. The Tmax and thet1/2 ranged from 1.1 to 2.5 hr and from 4.1 to 9.2 hr (t1/2α: 3.3 ± 1.0 ; t1/2β: 17.1 ± 4.1 hrin 120mg), respectively. The mean (±SE) of percent urinary excretion of unchanged drugwas 1.4 ± 0.3%. No side effect has been observed throughout the study period.
