Relationships between Urinary Levels of Ulinastatin and α₁-Microglobulin and the Severity of Alzheimer-Type or Vascular Dementia

抄録

Ulinastatin (urinary trypsin inhibitor) and α₁-microglobulin levels in urine samples of 39 dementia patients (Alzheimer-type dementia, 21 cases; vascular dementia, 18 cases) and 14 normal subjects were measured. There was a positive correlation between the ulinastatin and α₁-microglobulin levels. Lower scores on the dementia rating scale and activities of daily living were observed in patients with Alzheimer-type dementia but not with vascular dementia, where a lower α₁-microglobulin level was registered. However, the ulinastatin level did not correlate with the scores in patients with either Alzheimer-type or vascular dementia. These results indicate that the urinary ar-microglobulin level provides a useful biochemical index of the severity of Alzheimer-type dementia.