抄録
The purpose of the present study was to investigate the relationship between enalapril-induced cough and patient characteristics such as age, sex, smoking, dosage of enalapril, history of allergy and combined use of β-blockers in outpatients of 27 hospitals, 9 clinics and 16 pharmacies in Japan. The data of this cross-sectional study obtained through interview with patients taking enalapril, were analyzed by multiple regression analysis.
Of 3010 subjects, enalapril-induced coughing was found in 525 (17.4%). A significant correlation was found between cough and allergic factor, but the coefficient of determination was of low value (r2=0.0134, p<0.001). Furthermore, this odds ratio was 1.97 (95% CI, 1.60-2.43, p<0.001). These data suggest that allergic factors are related to enalapril-induced cough rather than background factors such as age, sex, smoking, dosage of enalapril and concomitant use of β-blockers.
