抄録
The effect of trimebutine on the digestive tract motility was studied in 4 healthy male volunteers by means of a crossover technique under the double-blind condition. The subjects were administered each dose of trimebutine 0, 100, 200 and 300mg in randomly assigned order, respectively on different days. An X-ray study was performed to evaluate the effect of trimebutine on gastric emptying time, gastric motility and intestinal transit time.
The results obtained were as follows:
1) Gastric emptying time showed a dose dependent increasing tendency and statistical significance was observed in the case given 200 mg or 300 mg of trimebutine in comparison with the case of 0 mg.
2) No influence of trimebutine on gastric tonus and gastric peristalsis was observed
3) Intestinal transit time tended to be slightly shorten, irrespective as to wheather it is due to direct or secondary effect of the drug.
